Nobody trumps my nana when it comes to this dish! 5 stars!

Preheat your oven to 400°F (200°C).

In a skillet over medium heat, cook the ground beef and chopped onion until the beef is browned and the onion is tender. Drain any excess fat.

Stir in the salt, black pepper, Worcestershire sauce, and ketchup. Mix well.

Transfer the beef mixture into a 9-inch pie plate and spread it evenly.

Sprinkle the shredded cheddar cheese over the beef mixture.

In a medium bowl, whisk together the milk, eggs, and Bisquick mix until smooth.

Pour the Bisquick mixture over the beef and cheese in the pie plate.

Bake in the preheated oven for 25-30 minutes, or until the top is golden brown and a knife inserted in the center comes out clean.

Allow the pie to cool for a few minutes before slicing and serving.

For a spicier version, add some chopped jalapeños or a dash of hot sauce to the beef mixture. You can also experiment with different cheeses, such as pepper jack or mozzarella, for a unique flavor profile. If you prefer a more traditional pie crust, you can use a pre-made pie crust instead of the Bisquick topping. For a healthier twist, consider using ground turkey or chicken in place of beef.